Zoledronic Acid CAS 118072-93-8 Purity ≥99.5% (HPLC)

Short Description:

Chemical Name: Zoledronic Acid 

CAS: 118072-93-8

Appearance: White to Off-White Crystalline Powder

Purity: ≥99.5% (HPLC)

In the Treatment of Hypercalcemia of Malignancy (HCM)

API High Quality, Commercial Production

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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118072-93-8 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Zoledronic Acid (CAS: 118072-93-8) with high quality, commercial production. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Zoledronic Acid, Please contact: alvin@ruifuchem.com 

118072-93-8 - Chemical Properties:

Chemical Name Zoledronic Acid
Synonyms ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera; [1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid
CAS Number 118072-93-8
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C5H10N2O7P2
Molecular Weight 272.09
Melting Point 193.0~204.0℃
Density 2.13±0.10 g/cm3
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

118072-93-8 - Specifications:

Item Specifications
Appearance White to Off-White Crystalline Powder
Identification  IR Spectrum of the sample corresponds to that of the reference standard
pH 2.0~4.0
Solubility Sparingly Soluble in 0.1N Sodium Hydroxide Solution, Slightly Soluble in Water and 0.1N Hydrochloric Acid, Practically Insoluble in Ethanol
Related Substances
Any Individual Impurity ≤0.10%
Total Impurities ≤0.30%
Loss on Drying 5.0%~7.0%
Chloride ≤0.02%
Phosphite ≤0.50%
Phosphate ≤0.50%
Heavy Metals ≤10ppm
Purity / Analysis Method ≥99.5% (HPLC)
Test Standard Enterprise Standard

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

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118072-93-8 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes R21/22 - Harmful in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
HS Code 2933990099

118072-93-8 - Application:

Zoledronic Acid (CAS 118072-93-8) is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50=20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB. Zoledronic acid was approved by the U.S. FDA in 2001 for the treatment of hypercalcemia of malignancy, a metabolic complication that can be life-threatening. Hypercalcemia of malignancy can occur in up to 50% of patients diagnosed with advanced breast cancer, multiple myeloma, and nonsmall cell lung cancer. This condition arises when chemical moieties produced by the tumor cause overstimulation of osteoclasts. When there is an increase in bone degradation, there is a concomitant release of calcium into the plasma. When serum concentrations of calcium rapidly elevate, the kidneys are unable to handle the overload, and hypercalcemia results. Zoledronic acid effectively decreases plasma calcium concentrations via inhibition of bone resorption (inhibition of osteoclastic activity and induction of osteoclast apoptosis). Additionally zoledronic acid has been approved by the U.S. FDA for the treatment of multiple myeloma and bone metastases associated with solid tumor-based cancers (e.g., prostrate and lung). 

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